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Advances in Pharmacology & Clinical Trials Research Article 6 min read

A Mini-Review of Antinociceptive Effects of Medicinal Plants from Hamedan, Iran

Mohammadi S*
* Corresponding author
ISSN: 2474-9214  10.23880/apct-16000123  Received: March 26, 2018  Published: April 11, 2018
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Keywords
Hamadan Medicinal Plants Antinociceptive Animal Model
Abstract

Numerous side effects of synthetic drugs have caused medicinal plants to be regarded in recent decades as a reliable source of new drugs. Regarding the analgesic effects of many plants that are pointed in raditional medicine of Hamadan province, many studies have been performed in this field that have caused need to be reviewed. In this study, medicinal plants belong to different family and also the possible mechanisms actions of these plants are presented. The data presented in this review paper provide scientific information that might be used for analgesic drugs production in future.

Introduction

Based on definition of international association of pain study, pain is an undesirable mental and motional experience that is associated with possible or actual damage of tissue or is created in some periods of these types of pains. Pain is created by different reasons such as harmful heat, stretch, electrical flow, necrosis, inflammation, laceration and spasm [1]. Pain is also caused by a wide variety of diseases, surgical interventions and trauma. Degenerative diseases like rheumatoid arthritis, polymyalgia rheumatica, as well as heart, asthma, cancer and inflammatory bowel diseases are also associated with inflammatory processes and pain. It is a complex experience in which cognitive, affective and behavioral features, representing psychological conditions are affected [2, 3]. In most cases, pain is secondary to other complications such as diabetic nephropathy [4]. More than 50million American populations due to involving in pain conditions are partially or totally disabled. The United States Center for Healthcare Statics carried out an eight-year study, demonstrating 32.8% U.S. populations were suffering from chronic pain [5]. Recent studies have shown that 22% of primary care patients suffered from pain which persists for more than six months and in some cases the percentage rises to 50% which is related to significant impairment of social functioning and quality of life [6]. Although pain mainly is considered as a defense mechanism which is created when a tissue is damaged and caused a person show reaction and remove pain stimulant [4], however, in sever condition it impairs social functioning and reduces quality of life [1]. Millions of people suffering from different types of damage who wish to find a drug with more effect and less side effects in order to release themselves from the pain [7]. Medicinal plants have been suggested to presence natural effective substances for prevention or treatment of pain related conditions. Drugs with herbal origin have attracted attention of researchers and people by having low or no side effects [8]. These medicinal plants mostly possess antioxidant activities [9] and other than pain and inflammation, are effective on a lot of hard curable diseases such as diabetes and cancer which may increase free radicals and result in pain [10, 11]. Regarding importance of valuable indigenous information on traditional treatments, and pain relief, this

Results

study was performed with the aim of documenting information of effective medicinal plants of Hamadan Province in treating the pain.

Material and Methods

All data were obtained by major database like Web of Science, Scopus, PubMed, Google Scholar, and etc.

Fractions and used
Family nameScientific namePain test typePossible mechanismRef
organism
AsteraceaeArtemisia
absinthium		Tail flick testHydroalcoholic leaf
extract		Opioid systems[12]
Calendula officinalisTail flick test, Writhing
test		Hydroalcoholic leaf
extract		Opioid systems[13]
Sonchus asperTail flick test, Writhing
test, Formalin,
Glutamate induced test.		Hydroalcoholic leaf
extract		Glutamatergic and opioid
systems		[14]
Inula britannicaTail flick test, Writhing
test, Formalin,
Glutamate induced test		Essential oilGlutamatergic, opioid
systems, L-
Arginine/NO/cGMP/
KATP pathway		[15]
Inula heleniumTail flick test, Writhing
test, Formalin		Hydroalcoholic leaf
extract		Opioid systems[16]
Erigeron acerTail flick test, Writhing
test, Formalin		Hydroalcoholic leaf
extract		Opioid systems[17]
AraliaceaeHedera helixTail flick test, WrithingHydroalcoholic leaf
extract		Opioid systems[18]
AnacardiaceaeRhus coriariaTail flick test, Writhing
test, Formalin,		Hydroalcoholic leaf
extract		Opioid systems[19]
ApiaceaeDucrosia anethifoliaTail flick test, Writhing
test, Formalin,		Essential oilOpioid systems[20]
Eryngium
pyramidale		Tail flick test, Writhing
test, Formalin,		Essential oil leafOpioid systems[21]
Pimpinella anisumTail flick test, Writhing
test, Formalin		Methanolic leaf extractOpioid systems[22]
ComositeaeTanacetum
balsamita		Tail flick test, Writhing
test, Formalin,		Essential oil leafOpioid systems[23]
CucurbitaceaeBryonia dioicaTail flick test, Writhing
test, Formalin,		Hydroalcoholic leaf
extract		Opioid systems[24]
LamiaceaeLallemantia ibericaTail flick test, Writhing
test, Formalin,		Hydroalcoholic leaf
extract		Opioid systems[25]
LiliaceaeAllium hirtifoliumTail flick test, Writhing
test, Formalin,		Hydroalcoholic leaf
extract		Opioid systems[26]
MalvaceaeAlthaea officinalisTail flick test, Writhing
test, Formalin		Essential oil leafOpioid systems[27]
OxalidaceaeBiophytum
sensivitum		Tail flick test, Writhing
test, Formalin		Hydroalcoholic leaf
extract		Opioid systems[28]
RosaceaePotentilla reptansTail flick test, WrithingHydroalcoholic leafOpioid systems[29]

test, Formalin extract

Passifloraceae Passiflora caerulea Tail flick test, Writhing

Umbelliferae Echinophora Tail flick test, Writhing

Platyloba test, Formalin

Verbenaceae Lemon Verbena Tail-flick, and writhing Aqueous extract Opioid systems [32]

Zygophyllaceae Tribulus terrestris Tail flick test, Writhing

test, Formalin

Conclusion

Our results from the present study have been shown that among the mentioned medicinal plants, Asteraceae family had used more than other family for evaluation of pain.

References

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@article{mohammadi2018,
  title   = {A Mini-Review of Antinociceptive Effects of Medicinal Plants from Hamedan, Iran},
  author  = {Mohammadi S},
  journal = {Advances in Pharmacology & Clinical Trials},
  year    = {2018},
  volume  = {3},
  number  = {1},
  doi     = {10.23880/apct-16000123}
}
Mohammadi S (2018). A Mini-Review of Antinociceptive Effects of Medicinal Plants from Hamedan, Iran. Advances in Pharmacology & Clinical Trials, 3(1). https://doi.org/10.23880/apct-16000123
TY  - JOUR
TI  - A Mini-Review of Antinociceptive Effects of Medicinal Plants from Hamedan, Iran
AU  - Mohammadi S
JO  - Advances in Pharmacology & Clinical Trials
PY  - 2018
VL  - 3
IS  - 1
DO  - 10.23880/apct-16000123
ER  -