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Bioinformatics & Proteomics Open Access Journal Research Article 11 min read

The Ploc Bal-Manimal is a Powerful Artificial Intelligence Tool for Predicting the Subcellular Localization of Animal Proteins Based on their Sequence Information Alone

Chou KC*
* Corresponding author
ISSN: 2642-6129  10.23880/bpoj-16000130  Received: January 29, 2020  Published: March 09, 2020
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 65 references
 2 figures
 1 table
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Keywords
Animal Protein Multi Label System Sequence Analyzing Method

Introduction

Recently a very useful web-server, or AI (Artificial Intelligence) tool, has been established for predicting the subcellular localization of animal proteins purely according to their sequences information for the multi-label systems [1], in which a same protein may occur or travel between two or more locations and hence its ID (identification) needs two or more labels as well, namely the “multi-label mark” [2]. The AI tool is named as “pLoc_bal-mAnimal”, where “bal” stands for that the AI tool has been treated by balancing out the training dataset [3], and “m” for that the AI tool bears the capacity to deal with the multi-label systems. Below, let us show how the AI tool is working.

PredictorAiming (↑)aCoverage(↑)aAccuracy(↑)aAbsolute true (↑)aAbsolute false (↓)a
pLoc-mAnimalb87.96%85.33%84.64%73.11%1.65%
pLoc_bal-Animalc93.22%96.54%93.00.%88.70%0. 57%
Figure 1
Click to enlarge
Figure 1
Figure 2: A semi screenshot for the webpage obtained by following Step 3 of Section 3.5 (Adapted from [3] with permission).
Click to enlarge
Figure 2: A semi screenshot for the webpage obtained by following Step 3 of Section 3.5 (Adapted from [3] with permission).

Clicking the link at http://www.jci-bioinfo.cn/pLoc_ bal-mAnimal/, you will see the top page of the pLoc_bal- mAnimal web-server prompted on your computer’s screen (Figure 1). Then, following the commands given in the Step 2 and Step 3 of [3], you will see (Figure 2) on the screen of your computer. The corresponding reports were detailed in Table 3 of [3]. You can see from there: nearly all the success rates achieved by the AI tool for the animal proteins in each of the 20 subcellular locations are within the range of 94- 100%. Such a high prediction quality is far beyond the reach of any of its counterparts.

In addition to the advantages of high accuracy and easy to use, the AI tool has been constructed by strictly complying with the “Chou’s 5-steps rule” and hence possesses the following terrific merits as concurred by many investigators (see eg. [4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22]) as well as three comprehensive review papers [2, 23, 24]):

  • Crystal clear in logic development
  • Completely transparent in operation
  • Easily to repeat the reported results by other investigators,
  • With high potential in stimulating other sequence- analyzing methods, and
  • Very convenient to be used by the majority of experimental scientists.

Besides, the approach [25, 26, 27] of PseAAC (Pseudo Amino Acid Composition) has also been used during the development of the AI tool. It is a very powerful approach for formulating the samples of proteins by catching their special features, as done by many investigators (see, eg., [28,29,30-

45]).

For the wonderful and awesome roles of the “5-steps rule” in driving proteome, genome analyses and drug development, see a series of recent papers [46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65] where the rule and its wide applications have been very impressively presented from various aspects or at different angles.

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BibTeX
APA
RIS
@article{chou2020,
  title   = {The Ploc Bal-Manimal is a Powerful Artificial Intelligence Tool for Predicting the Subcellular Localization of Animal Proteins Based on their Sequence Information Alone},
  author  = {Chou KC},
  journal = {Bioinformatics & Proteomics Open Access Journal},
  year    = {2020},
  volume  = {4},
  number  = {1},
  doi     = {10.23880/bpoj-16000130}
}
Chou KC (2020). The Ploc Bal-Manimal is a Powerful Artificial Intelligence Tool for Predicting the Subcellular Localization of Animal Proteins Based on their Sequence Information Alone. Bioinformatics & Proteomics Open Access Journal, 4(1). https://doi.org/10.23880/bpoj-16000130
TY  - JOUR
TI  - The Ploc Bal-Manimal is a Powerful Artificial Intelligence Tool for Predicting the Subcellular Localization of Animal Proteins Based on their Sequence Information Alone
AU  - Chou KC
JO  - Bioinformatics & Proteomics Open Access Journal
PY  - 2020
VL  - 4
IS  - 1
DO  - 10.23880/bpoj-16000130
ER  -