Relationship of Rodents with Corona Viruses Infection- An Overview

Study References

A new virus, isolated from the lungs of mice, spreads to mice bred in wild colonies and leads to fatal pneumonia in newborn mice. Classified as rat coronavirus (RCV), the virus exhibits representative properties of the coronavirus group: these are useful for antibody detection useful in sero- epidemiologie studies Parker, et al. [1]. The alpha coronavirus and betacoronavirus were detected in mice, Apodemus chevrieri in the Yunnan Province of China, indicating that Apodemus chevrieri is an important host of coronaviruses. Several new features have been identified in the genome of the Apodemus chevrieri coronavirus.

The genetic distance to other coronaviruses indicates the variable origin and evolutionary pathway of the S genes of AcCoV-JC34, LRNV, and HKU2, and these results indicate that the diversity of the coronavirus for rodents is much higher than previously expected. Further surveillance and functional studies of these coronaviruses will help to better understand rodents as host of coronaviruses, Xing-Yi Ge, et al. [2]. Rat coronaviruses are highly infectious, as they are transmitted to infected mice by direct contact with infected rats, and indirectly by aerosols and fomites [3]. During outbreaks, morbidity is high, but mortality is very low [4]. The virus is present in the target tissues for about a week Commentary after exposure, at which time the levels of the antibody increase the infection. However, immunity is not for life.

Under experimental conditions, it was found that mice are susceptible to infection again with a homogeneous strain as early as 6 months after the initial infection and that these mice are able to transmit infection to naive mice by contacting the cage. However, the severity of lesions in infected mice is very small compared to those associated with primary infection [5, 6].

Coronaviruses are a large group of viruses common in animals. Sometimes people get infected with these viruses which may then spread to other people. For example, SARS- CoV has been associated with civet cats and the MERS- CoV virus that causes Middle East respiratory syndrome is transmitted by Arab camels. Potential animal sources of COVID-19 have not been confirmed [7].

Conclusion

• Rodents are important reservoirs of many pathogens example Coronaviruses.
• The previously infected mice have a lower degree of infection in future periods.
• The evolution and ecology of coronaviruses in rodent have not been fully investigated to human.
• A study of the immune system of infected rodents can be used to control the effect of coronaviruses on humans, especially the Coronavirus (COVID-19), it spreads all over the world and causes many deaths in the current period. From this, can also possible to study the immune system of people who have recovered from the disease in search of a new Therapy that useful all of humanity.