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Haematology International Journal Research Article 1 min read

Coadunation and Immixture-EWSR1: SMA3 Fibroblastic Tumour

Bajaj A*
* Corresponding author
ISSN: 2578-501X  10.23880/hij-16000217  Received: June 05, 2023  Published: June 09, 2023
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 5 references
 2 figures
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Keywords
Fibroblastic Tumour
Abstract

EWSR1::SMAD3 fibroblastic tumour is an extremely exceptional, contemporary, benign mesenchymal neoplasm of fibroblastic origin demonstrating varied morphological patterns, characteristic genetic fusions and localized tumour aggression. Tumefaction is predominantly situated upon extremities and exhibits an intense predilection for acral segments. Characteristic diagnostic features appear as a miniature neoplasm confined to acral cutaneous or subcutaneous tissue demonstrating a zonal configuration with hypo-cellular or acellular, hyalinised centric zone and intersecting fascicles of monomorphic, peripheral spindle shaped cells which appear immune reactive to ERG. EWSR1::SMAD3 genetic fusion is observed which assists cogent tumour classification. Neoplasm manifests a sporadic disease emergence

Figures

Figure 1: EWSR1::SMAD3 fibroblastic tumour delineating a lobulated neoplasm composed of an acellular, hyalinised centric zone surrounded by peripheral fascicles of spindle shaped cells. Cellular atypia, pleomorphism and mitotic activity is negligible [5,6].
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Figure 1: EWSR1::SMAD3 fibroblastic tumour delineating a lobulated neoplasm composed of an acellular, hyalinised centric zone surrounded by peripheral fascicles of spindle shaped cells. Cellular atypia, pleomorphism and mitotic activity is negligible [5,6].
Figure 2: EWSR1::SMAD3 fibroblastic tumours demonstrating a nodular neoplasm composed of hyalinised centric area circumscribed by peripheral fascicles of uniform spindle shaped cells lacking pleomorphism or atypia [7].
Click to enlarge
Figure 2: EWSR1::SMAD3 fibroblastic tumours demonstrating a nodular neoplasm composed of hyalinised centric area circumscribed by peripheral fascicles of uniform spindle shaped cells lacking pleomorphism or atypia [7].

References

  1. Antonescu CR, Suurmeijer AJH (2020) EWSR1- SMAD3-positive fibroblastic tumour (emerging). WHO classification of tumours, 5th (Edn.), In: Soft tissue and bone tumours. Lyon, France: IARC Press, pp: 76-77.
  2. Yang L, Fan L, Yin Z, Liu Y, Zhao D, et al. (2022) EWSR1:: SMAD3-rearranged fibroblastic tumor: A case with twice recurrence and literature review. Front Oncol 12: 1017310.
  3. Habeeb O, Korty KE, Azzato EM, Astbury C, Farkas DH, et al. (2021) EWSR1-SMAD3 rearranged fibroblastic tumor: Case series and review. J Cutan Pathol 48(2): 255-262.
  4. Foot O, Hallin M, Jones RL, Sumathi VP, Thway K (2021) EWSR1-SMAD3-Positive fibroblastic tumor. Int J Surg Pathol 29(2): 179-181.
  5. Michal M, Berry RS, Rubin BP, Kilpatrick SE, Agaimy A, et al. (2018) EWSR1-SMAD3-rearranged fibroblastic tumor: An emerging entity in an increasingly more complex group of Fibroblastic/Myofibroblastic neoplasms. Am J Surg Pathol 42(10): 1325-1333.
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@article{bajaj2023,
  title   = {Coadunation and Immixture-EWSR1: SMA3 Fibroblastic Tumour},
  author  = {Bajaj A},
  journal = {Haematology International Journal},
  year    = {2023},
  volume  = {7},
  number  = {1},
  doi     = {10.23880/hij-16000217}
}
Bajaj A (2023). Coadunation and Immixture-EWSR1: SMA3 Fibroblastic Tumour. Haematology International Journal, 7(1). https://doi.org/10.23880/hij-16000217
TY  - JOUR
TI  - Coadunation and Immixture-EWSR1: SMA3 Fibroblastic Tumour
AU  - Bajaj A
JO  - Haematology International Journal
PY  - 2023
VL  - 7
IS  - 1
DO  - 10.23880/hij-16000217
ER  -